Phospholipase a2 receptor antibody pla2r

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August undefined, 2024

WebBackground: The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction. The effects of anti-PLA2R antibodies directly to the podocytes remain unclear. WebObjective To explore the value of anti-phospholipase A2 receptor (PLA2R) antibody in the diagnosis and disease activity monitoring of idiopathic membranous nephropathy …

Expression of phospholipase A2 receptor and IgG4 in patients …

WebAnti-phospholipase A2 receptor antibody levels at diagnosis predicts spontaneous remission of idiopathic membranous nephropathy. AU Jullien P, Seitz Polski B, Maillard N … WebIn 2009, Beck et al 2 first discovered that the extracellular domain of phospholipase A2 receptor (PLA2R) was used as the mutant antigen to activate autoimmunity response. … births deaths and marriages queensland

Phospholipase A2 Receptor (PLA2R) Antibody, ELISA

Web因此有学者提出，磷脂酶A2可评估IMN的临床疗效与预后。本文拟对此研究状况做以综述。一、PLA2R的结构. PLA2R属于甘露糖受体（Mannose Receptor，MR）家族，1989年由Stanescu等[5]首次对其做了报道。迄今为止，共发现了两个亚型的PLA2R——M型和N型[6]。 WebMar 21, 2024 · PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging. Phospholipase A2 receptor 1 promotes lung cell senescence and … WebAnti-PLA2R antibody [CL0474] (ab188028) Datasheet SDS Submit a review Submit a question References (2) Key features and details Mouse monoclonal [CL0474] to PLA2R Suitable for: IHC-P, WB, ICC Reacts with: Human Isotype: IgG1 You may also be interested in Primary Anti-Ext1 antibody (ab126305) Peptide PLA2R peptide (ab176432) births deaths and marriages register

Anti-phospholipase A2 receptor antibody levels at diagnosis …

Ultrasensitive Quantitation of Anti-Phospholipase A2 Receptor Antibody …

WebPhospholipase A2 Receptor (PLA2R) Antibody Panel This test is used to differentiate primary membranous nephropathy from secondary membranous nephropathy, and … WebThrombospondin Type-1 Domain-Containing 7A Antibodies, Serum Specimen Fees & Codes Setup & Updates Useful For Distinguishing primary from secondary membranous nephropathy cases with antibodies against THSD7A Method Name Indirect Immunofluorescence Assay (IFA) NY State Available Yes Reporting Name THSD7A Ab, S … darf cod 8741WebMay 29, 2024 · The aims of this study were to detect the expression of M phospholipase A2 receptor (PLA2R) in the kidney tissue of patients with idiopathic membranous nephropathy (IMN), secondary membranous nephropathy (SMN), and the nonmembranous nephropathy (non-MN), to evaluate the value of PLA2R in the kidney tissue and serum anti-PLA2R … births deaths and marriages register search

"WebJun 15, 2024 · Materials and methods: An open-label prospective comparative study included 56 PMN patients (pts) with nephrotic syndrome (NS) and high serum level of antibodies to the phospholipase A2 receptor anti-PLA2R (mean age 5112 years, men 70%). We recorded demographic and clinical parameters at the time of kidney biopsy, data from … " - Phospholipase a2 receptor antibody pla2r

Phospholipase a2 receptor antibody pla2r

WebAbstract. Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy … WebFeb 20, 2024 · M-type phospholipase A2 receptor 1 (PLA2R) has been described as a major antigen in iMN, with anti-PLA2R antibodies (Abs) present in ∼70% of incident patients [ 2, 3 ]. The specificity of anti-PLA2R Abs for the diagnosis of iMN, albeit not absolute, is now well established [ 3–5 ].

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Web180 kDa secretory phospholipase A2 receptor antibody; C-type lectin domain family 13 member C antibody; CLEC13C antibody; M type receptor antibody; ... Ramachandran R et al. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians. WebMay 24, 2024 · Anti-PLA2R antibodies are highly specific to primary MN, however anti-PLA2R antibodies have been identified in some secondary MN such as hepatitis B (HBV) and C (HCV), use of non-steroidal anti-inflammatory drugs, ... PLA2R: Phospholipase A2 receptor: SLE: Systemic lupus erythematosus:

WebJun 29, 2016 · The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay … WebBackground: The presence of antibodies against phospholipase A2 receptor (PLA2R-Abs) in serum at diagnosis is reported to be related to the rate of spontaneous remission in patients with idiopathic membranous nephropathy (IMN); however, there is still lack of enough samples to illustrate this problem. Here, we conducted a comprehensive meta-analysis to …

WebIn 2009, Beck et al 2 first discovered that the extracellular domain of phospholipase A2 receptor (PLA2R) was used as the mutant antigen to activate autoimmunity response. Combined with the PLA2R antibodies produced in the body, PLA2R forms the insitus immune complex, resulting in the injury of basement membrane, which was the major … WebPhospholipase A2 Receptor (PLA2R) Antibody, IgG with Reflex to Titer 2011828 Copy Utility Click to copy Test Number / Name Choose the Right Test ARUP Consult® assists with …

WebMar 5, 2015 · Hoxha, E. et al. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int. 82, 797–804 (2012).

WebObjective To explore the value of anti-phospholipase A2 receptor (PLA2R) antibody in the diagnosis and disease activity monitoring of idiopathic membranous nephropathy (IMN).Methods A total of 233 patients with IMN proven by kidney biopsy at Peking Union Medical College Hospital from January 2012 to March 2014 were enrolled in this study ... births deaths and marriages sa onlineWebAnti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy. As many as 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R. This test can be used to identify … births deaths and marriages registration actWebMar 11, 2024 · Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) with circulating serum autoantibodies to PLA2R (SAb+) but no deposits of PLA2R antigen in glomerular tissue by immunofluorescence (GAg−) has been reported. However, little is known about the clinicopathological characteristics or prognosis of this subtype of … births deaths and marriages scotland onlineWebSep 18, 2024 · Currently, serum M-type phospholipase A2 receptor antibody (sPLA2R-ab) is emerging as a predictive biomarker for early prognosis of PMN. In 2009, Beck et al. [ 2 ] … darf cofinsWebRecent clinical studies have revealed that circulating autoantibodies to the podocyte M-type receptor for secretory phospholipase A2 (PLA2R) can be measured in 70% to 80% of … births deaths and marriages south australiaWebHave a medical condition that can cause damage to the kidneys including cancer and lupus. Symptoms and Causes What causes membranous nephropathy (MN)? Most cases of MN are now known to be caused by an antibody to a protein on the podocyte called the phospholipase A2 receptor (PLA2R). darf cofins 2172WebApr 15, 2024 · Both blood phospholipase A2 receptor -Ab and kidney tissue phospholipase A2 receptor were negative. Thirty-six patients received glucocorticosteroids and/or … births deaths and marriages reading berkshire