Lxr gene card

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August undefined, 2024

WebMar 19, 2015 · LXRs and LXR ligands have tissue-specific functions and mechanisms, and the heterogeneity of the different types of cancers and the emerging mechanistic … WebLXRs bind to the promoters of specific target genes as heterodimers with the retinoid X receptor (RXR; NR2B1). The sequence elements identified by the LXRs are direct repeat …

NR1H2 Gene - GeneCards NR1H2 Protein NR1H2 …

WebFeb 1, 2004 · The nuclear receptors liver X receptor (LXR)α and LXRβ are sensors of cholesterol metabolism and lipid biosynthesis. They have recently been found to be … WebLiver X Receptor. LXR is a sterol sensor that promotes lipogenesis, whereas PPARα controls a variety of genes in several pathways of lipid metabolism. ... Scd1 is eliminated … linder library catalog

Role of liver X receptors in cholesterol efflux and inflammatory ...

WebLiver X receptor (LXR) α and LXRβ (encoded by Nr1h3 and Nr1h2) play important roles in hepatic lipid metabolism. LXRs are crucial for the lipogenic response to feeding as … WebFeb 2, 2024 · The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic metabolism. Many genes induced in response to pharmacologic LXR agonism have been defined; however, the transcriptional consequences of loss of LXR binding to its genomic targets are less well characterized. WebLXR-RXR complex is linked to the responsive element LXR (LXRE) in DNA, a region of direct repetition 4 (DR4), recognized as the consensus sequence (5′-AGGTCA-NNNN … hot house corea

NR1H3 Gene - GeneCards NR1H3 Protein NR1H3 …

Liver X receptor alpha - Wikipedia

WebLiver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). [5] WebOct 1, 2009 · Liver X receptor-alpha (LXR-α), being a member of the nuclear receptor/transcription factor family, has been widely recognized to have a pleiotropic effect in the regulation of genes involved in ... hothouse cosmeticsThe liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. Additionally, they play an important role in the local activation of thyroid hormones via deiodinases. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ i… linder machinery used equipment

"WebLXRs bind to the promoters of specific target genes as heterodimers with the retinoid X receptor (RXR; NR2B1). The sequence elements identified by the LXRs are direct repeat four (DR4)-type motifs, termed LXR responsive elements (LXREs; Repa and Mangelsdorf, 2000; Tontonoz and Mangelsdorf, 2003). " - Lxr gene card

Lxr gene card

Liver X Receptor Alpha - an overview ScienceDirect …

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands they were subsequently deorphanized. WebJun 7, 2013 · Liver X receptor (LXR) activation improves glucose homeostasis in obesity. This improvement, however, is associated with several side effects including hyperlipidemia and hepatic steatosis. Activation of peroxisome proliferator-activated receptor alpha (PPARα), on the other hand, increases fatty acid oxidation, leading to a reduction of …

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WebNational Center for Biotechnology Information WebFeb 24, 2024 · Liver X Receptors (LXR) control cholesterol metabolism and exert anti-inflammatory actions but their contribution to human macrophage polarization remains …

WebJun 14, 2024 · LXRs bind to and regulate the expression of genes that encode proteins involved in cholesterol absorption, transport, efflux, excretion and conversion to bile … WebNov 8, 2013 · Direct LXR target genes include those encoding the ATP-binding cassette (ABC) transporter A1 (ABCA1) and the ABC transporter G1 (ABCG1), which govern cholesterol efflux from macrophages and peripheral organs, and the inducible degrader of LDL receptor ( Idol [also known as Mylip ]), which decreases LDL receptor protein levels …

WebMar 19, 2015 · Apolipoprotein E (APOE) is an LXR target gene that has been implicated in the suppression of metastasis in melanoma models 89. Melanoma cells treated with LXR ligands showed increased APOE... WebThe liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and phospholipid metabolism. Dynamic remodeling of immunometabolic pathways, including …

WebJan 17, 2012 · The LXR/RXR is a so-called permissive heterodimer; in that it can be activated by ligands for either LXR or RXR. The heterodimer binding to LXR-responsive elements (LXREs) in DNA consists of direct repeats (DRs) of the core sequence AGGTCA separated by 4 nucleotides (DR-4).

WebFeb 24, 2024 · LXRα and LXRβ (coded for by NR1H3 and NR1H2, respectively) are ligand-activated transcription factors that regulate gene expression (positively and negatively) in a ligand-dependent manner, and that actively control macrophage differentiation and specialization ( 28 – 30 ). hothouse creations gangsters free downloadWebMar 21, 2024 · Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor subfamily, which form heterodimers with … hothouse creativeWeb1973 TOPPS VINTAGE CARD SIGNED AUTO GENE WASHINGTON MINNESOTA VIKINGS GREAT. $7.99 + $3.50 shipping. 1973 TOPPS GENE WASHINGTON MINNESOTA VIKINGS #359. $4.00. Free shipping. 1973 TOPPS GENE WASHINGTON MINNESOTA VIKINGS #359. $4.00. Free shipping. Picture Information. Picture 1 of 1. … linder machinery companyWebLXRbeta is involved in the control of platelet production from megakaryocytes. Liver X Receptor beta Related to Tumor Progression and Ribosome Gene Expression in … linderman creek apartmentsWebLiver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. There are two LXR isoforms termed alpha and beta which upon activation … hot house covering linderman education center kalispell mtWebNov 15, 2024 · Lipidomic and transcriptomic analysis of in vivo macrophage foam cells demonstrate that desmosterol is a major endogenous liver X receptor (LXR) ligand involved in LXR/retinoid X receptor (RXR) activation and thus macrophage foam cell … hothouse covers