WebHowever, one homeodomain protein, HOPX, is unique among its family members in that it lacks the capacity to bind DNA and instead functions by interacting with transcriptional regulators. HOPX... Web1 nov. 2015 · In the adult brain, Hopx is expressed in the cerebellum (Fig. 1 A) in both Purkinje cells and Bergmann glial cells (Fig. 1 B).In the hippocampus, Hopx is found in mature astrocytes, but not in mature oligodendrocytes or neurons (Fig. 1 C–E).We note that Hopx + astrocytes are primarily located in the CA regions, but rare Hopx + astrocytes …

Hopx distinguishes hippocampal from lateral ventricle neural stem cells ...

WebHOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, … Web29 jul. 2024 · HOPX is an atypical transcription factor whose homeodomain lacks the ability to bind DNA; instead, it regulates DNA transcription indirectly through binding to other transcription factors . HOPX has been established as a marker of radial glia, and its expression is increased during neurodevelopment, as well as in the neurogenic niches of … sample financial dashboard reports

HOPX: A Unique Homeodomain Protein in Development and …

WebConclusion: Our data showed that HOPX, a tumor suppressor, is epigenetically silenced in breast cancer. Overexpression of HOPX could suppress the progression of breast cancer, and thus indicating that it might serve as a potential target for the treatment of patients with breast cancer. Keywords: breast cancer, DNA methylation, HOPX, apoptosis. WebHopx. The outflow tract is also enriched for bone morphogenetic protein (Bmp) signal-ing, known to influence differentiation of myocytes. Hopx physically interacts with activated Smad complexes in vitro and in vivo. Exogenous Bmp4 represses Wnt signaling in cardiac explants, and Bmp4-mediated Wnt repression requires Hopx. Thus, Hopx func- WebOur HOPX polyclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Relative expression to confirm specificity to HOPX. Find the HOPX antibody that fits your needs. Choose from 1 of 10 HOPX antibodies, which have been validated in experiments with 2 publications and 27 images featured in our data gallery. sample financial plan in business plan