Clec12a marker
WebEarlier studies identified the transmembrane cell surface C-type lectin CLEC14A as a putative tumour endothelial marker. For CLEC14A to progress as a vascular target in solid tumours an in-depth analysis of CLEC14A expression in human healthy and tumour tissue is … WebMar 16, 2024 · CLEC12A belongs to the dectin gene cluster and is a transmembrane cell surface receptor expressed mainly on myeloid cells that binds monosodium urate (MSU) crystals. MSU crystals are DAMPs formed...
Clec12a marker
Did you know?
WebNov 16, 2024 · CLEC12A is highly expressed by AML cells and most importantly, it is present on LSCs but not healthy HSCs. I developed a TriKE against CLEC12A (CLEC12A TriKE) (Figure 1A). This TriKE was able... WebJul 30, 2024 · On the other hand, cDC2s, defined mainly by CD11b and CD172a (SIRPα) expression, constitute heterogeneous cell types with differential surface expression of …
WebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn … WebCLEC12A. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.
WebFeb 25, 2024 · CLEC12A-directed CAR T-cell therapy has been recently reported to induce remission in a pediatric patient with secondary AML, who was in remission at the time of … WebCLEC12A high was positively associated with immune checkpoint genes as well as macrophage associated genes. CLEC12A is an ideal chimeric antigen receptor T-cell …
WebNov 19, 2024 · A distinct subset of T-bet – cDC2s express Rorc, Tmem176a, Tmem176b, Clec12a, Cx3cr1, Cd14, Il1a and P2rx7. cDC2s acquire these specific transcriptional profiles in the periphery, probably in...
WebMar 29, 2024 · Revisiting CLEC12A as leukaemic stem cell marker in AML: highlighting the necessity of precision diagnostics in patients eligible for targeted therapy. these data can … macbook pro small video windowWebThe C-type lectin domain family 12, member A (CLEC12A) receptor has emerged as a leukaemia-associated and cancer stem cell marker in myeloid malignancies. However, a detailed delineation of its expression in normal haematopoiesis is lacking. macbook pro small thingsWebCLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout … macbook pro slow sd cardWebCD51 + CD61 (Integrin alpha V + Integrin beta 3) CD51 / Integrin alpha V. CD52 kitchen paint colors maple cabinetsWebAug 26, 2024 · Clec12A (also known as MICL, CLL-1, or DCAL-2) is a prototypic ITIM-containing CLR that is predominantly expressed on myeloid cells (9, 10).Earlier studies have demonstrated that Clec12A couples to SHP-1 and SHP-2 after SFK-mediated ITIM phosphorylation ().Moreover, recent work identified Clec12A as a specific receptor for … kitchen paint colors sherwin williamsWebMar 1, 2024 · The CLEC12A gene is located on chromosome 12p13 in a region near a cluster of C-type lectins/NK gene complex [19,20] and encodes 6 exons [21,22. … kitchen paint color ideas with light cabinetsCLEC12A, also known as MICL, is inhibitory C-type lectin-like receptor. It contains ITIM motif in cytoplasmic tail that can associate with signaling phosphatases SHP-1 and SHP-2. There are two types, human (hMICL) and murine (mMICL). See more C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) … See more In the immunotherapy of acute myeloid leukemia (AML), CLL-1 becomes one of the target due to its high expression in AML cells while … See more • Human CLEC12A genome location and CLEC12A gene details page in the UCSC Genome Browser. See more • Drickamer K (October 1999). "C-type lectin-like domains". Current Opinion in Structural Biology. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3 See more macbook pro slow wifi speed