Cisplatin mechanism of hearing loss

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August undefined, 2024

WebJun 21, 2024 · In this trial, the addition of delayed sodium thiosulfate to cisplatin led to a 48% lower risk of hearing loss. Hearing loss of grade 1 or higher occurred in 63% of the children who did... WebApr 17, 2024 · Late-onset hearing loss is known to occur long after cessation of cisplatin treatment, and these study results suggest that this delayed hearing loss may be related to long-retained cisplatin in the cochlea. Until researchers make significant progress in preventing cisplatin ototoxicity in cancer therapy, it is crucial to continue identifying ...

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WebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the … cssng.web.att.com:8080/css-ng/welcome.do

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WebOct 8, 2012 · The mechanism of accumulation is unknown, but is thought to be by way of carrier-mediated transport in the case of cisplatin, ... Cisplatin-induced hearing loss is related to activation of STAT1. (A) … WebJul 7, 2024 · Cisplatin is a highly effective treatment for malignant cancers and has become a cornerstone in chemotherapeutic regimens. Unfortunately, its use in the clinic is often … WebMar 1, 2024 · Although the mechanisms behind cisplatin-associated ototoxicity have not been completely explained, it may mainly involve ROS accumulation in the inner ear, causing a significant increase in lipid peroxidation, consumption of intracochlear antioxidants, and calcium influx, subsequently inducing apoptosis5. earls do all garage

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

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WebAug 25, 2024 · This hypothesis was supported by the late increase in hearing loss after a single dose of cisplatin, emphasizing the role of the supporting cells in the cochlear … WebMay 19, 2016 · Dr. Chang's clinical practice is based at the Lucile Packard Children's Hospital, and is focused on Pediatric Otology. He has specific … cssng web attWeb20 hours ago · The drug, which is Fennec's sole product, is intended to prevent hearing loss in pediatric cancer patients treated with cisplatin chemotherapy. earls dog food pate

"WebThe SGN apoptosis and related hearing loss induced by cisplatin were alleviated after co-treatment with the autophagy activator rapamycin, whereas these were exacerbated by the autophagy inhibitor 3-methyladenine, indicating that instead of inducing SGN death, autophagy played a neuroprotective role in SGNs treated with cisplatin both in ... " - Cisplatin mechanism of hearing loss

Cisplatin mechanism of hearing loss

Matthew Reiss, PhD - Boston University School of Medicine

WebCisplatin is an essential chemotherapeutic agent in the treatment of many pediatric cancers. Unfortunately, cisplatin-induced hearing loss (CIHL) is a common, clinically … WebAug 1, 2024 · These cisplatin-induced side effects can have a major impact on patient quality of life, including social development problems in pediatric patients that develop hearing loss. Previous...

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WebSpecifically, E1A/Ras- transformed S47 cells show increased sensitivity to cisplatin and paclitaxel, and comparable transactivation of GLS2 and SCO2, compared to cells with WT p53. WebMar 25, 2024 · Cisplatin is considered one of the most ototoxic pharmacologic agents, typically causing bilateral high frequency sensorineural hearing loss with progression to lower frequencies with continued exposure.

WebFeb 1, 2024 · loss of appetite loss of balance loss of hearing lower back or side pain nausea or vomiting painful or difficult urination pinpoint red spots on skin ringing or … WebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk …

WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced ototoxicity in vitro and in vivo. Sprague–Dawley rats (SD, 8 … WebApr 6, 2016 · Significance statement: Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. Its use results in significant and permanent hearing loss, for which no US Food and Drug Administration-approved treatment is currently available.

WebApr 7, 2024 · The benefit of Pedmarqsi is preventing cisplatin-induced hearing loss, as evaluated in a phase III, randomised, open-label study in children with standard-risk hepatoblastoma and treated with cisplatin alone or in combination with Pedmarqsi. The most common side effects are vomiting, nausea, hypernatraemia, hypophosphataemia …

WebFeb 11, 2024 · Cisplatin is used to treat a wide range of childhood cancers and cisplatin-induced hearing loss (CIHL) is a common and debilitating … cssni3 phase transition temperatureWebJul 2, 2024 · The ABR threshold shift in animals treated with caffeine + R -PIA + cisplatin was 1.0 ± 1.0, 3.3 ± 1.7 and 4.2 ± 0.8 at 8, 16 and 32 kHz, respectively. These findings … earls dog food aldiWebSep 1, 2024 · Cisplatin for injection can cause ototoxicity, which is cumulative and may be severe. Consider audiometric and vestibular function monitoring. Ototoxicity is manifested by tinnitus, hearing loss in the high frequency range (4,000 to 8,000 Hz) and/or decreased ability to hear normal conversational tones. css niceWebFeb 9, 2016 · INTRODUCTION. Ototoxicity, manifesting as hearing loss, tinnitus, and/or vertigo, is a well-established toxicity associated with a subgroup of antineoplastic therapies that include platinum chemotherapy and radiation or surgery involving the ear and auditory nerve. Supportive care agents, such as aminoglycoside antibiotics and loop diuretics ... earls dog foodWebApr 17, 2024 · Late-onset hearing loss is known to occur long after cessation of cisplatin treatment, and these study results suggest that this delayed hearing loss may be … cssni3 synthesisWebJul 11, 2024 · The mechanism of cisplatin-induced hearing loss remains unclear. Oxidative stress injury, inflammation, apoptosis and autophagy play an important role in the pathogenesis of cisplatin-induced hearing loss ( Gentilin et al., 2024 ). cssng_reporthome - report managerWebMar 26, 2024 · Acquired hearing loss may have multiple causes, but one of the common causes in childhood follows treatment for childhood cancer with cisplatin. For a sound to be perceived, it has to travel through the … earlsdon avenue north map