WebApr 12, 2024 · In the end, the kidney is heavily involved in the elimination of the drugs, and, as a consequence, kidney damage can lead to an altered excretion of the drugs and … WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has …
Significance of downregulation of renal organic cation transporter ...
WebFeb 16, 2016 · In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events (CTCAE). Using these criteria nephrotoxicity ≥grade 3 occurs in only 4%–9% of patients [ 7, 10, 11 ]. WebMay 8, 2024 · Nephrotoxicity With Cisplatin Patients may accumulate metabolites in the renal proximal tubule cells of the kidneys, where 90% of cisplatin undergoes urinary excretion, Duffy et al. explained. This causes a trifecta of factors: direct inflammation, production of reactive oxygen species leading to oxidative cell damage, and cell death. fk lightplanes fk 12
Chronic effects of repeated low-dose cisplatin treatment in mouse ...
Webing on pathologic examination of human kidneys affected by cisplatin toxicity. Both proximal and distaltubulesareaffected,andinpatientswithAKI, there is usually acute tubular necrosis. Long-term cisplatin exposure may also cause cyst formation and interstitial fibrosis (Figure 1) (3). Patients with cisplatin toxicity typically present WebTubular epithelial cells (TECs) is one of the most damaged cells in cisplatin induced AKI ( Xu et al., 2015 ). The well-known mechanism by which cisplatin exerts its anticancer effects—DNA damage—also affecting renal cells ( Tchounwou et al., 2024 ). WebApr 12, 2005 · Oxaliplatin is an antitumoral agent derived from platinum (trans-1,2-diammino-cylo-hexane-platinum) with cytotoxic activity against a number of solid tumours, including colorectal cancer and metastatic ovarian carcinoma. Renal side-effects are unclear. We report the second case of acute renal failure following the use of oxaliplatin. cannot import name print_function from future